MALICKI LAB RESEARCH

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Amacrine cells of the vertebrate retina consist of many diverse subpopulations. Four of such subpopulations are visualized above in the zebrafish retina. We are studying genetic mechanisms that generate and maintain amacrine cell diversity. (ANDREI AVANESOV)

Vertebrate photoreceptor development involves intraflagellar transport machinery that transports polypeptides from the cell body into the outer segment along the connecting cilium. A component of this machinery (red) as well as the connecting cilium (green) are missing in a zebrafish mutant. cc = connecting cilium; prcl = photoreceptor cell layer (MOTOKAZU TSUJIKAWA)

Cross section through a mosaic zebrafish retina. Photoreceptor cells (blue), Mueller glia (green), and a genetically distinct clone of cells (red) are shown. (GEOFF DOERRE)

The retina of wild type zebrafish and the mutant nagie oko. Cells of the mutant retinae are grossly disorganized. The patterns of interplexiform neurons in wild type (left) and mutant (right) are shown in the lower two panels. (XIANGYUN WEI)

Some of the cell type-specific expression patterns revealed in an in situ hybridization screen of embryonic transcripts. In panel A, expression appears to be confined to recently generated ganglion cells (margin of the retina). In B through D, expression is specific to the inner portion of the inner nuclear layer - presumably amacrine cells. (ZAC PUJIC, COLLABORATION WITH CHRISTINE AND BERNARD THISSE)

Morphological reconstruction of adult zebrafish ear. Classical drawing of a teleost ear presented by Wohlfahrt is shown in panel A. Computer aided 3D reconstructions of zebrafish ear are shown in B (pars superior) and C, D (pars inferior). Panel D also shows sinus impar (yellow). (PASCAL BANG, COLLABORATION WITH BILL SEWELL)